Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders
Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis. Genetic defects in microglia lead to microglial dysfunction, which in turn leads to neurological disorders. The correction of the specific genetic d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2024-03-01
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| Series: | Fundamental Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325823000778 |
| _version_ | 1797248222868013056 |
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| author | Yanxia Rao Bo Peng |
| author_facet | Yanxia Rao Bo Peng |
| author_sort | Yanxia Rao |
| collection | DOAJ |
| description | Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis. Genetic defects in microglia lead to microglial dysfunction, which in turn leads to neurological disorders. The correction of the specific genetic defects in microglia in these disorders can lead to therapeutic effects. Traditional genetic defect correction approaches are dependent on viral vector-based genetic defect corrections. However, the viruses used in these approaches, including adeno-associated viruses, lentiviruses and retroviruses, do not primarily target microglia; therefore, viral vector-based genetic defect corrections are ineffective in microglia. Microglia replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy microglia. In this paper, we systematically review the history, rationale and therapeutic perspectives of microglia replacement, which would be a novel strategy for treating CNS disorders. |
| first_indexed | 2024-04-24T20:11:10Z |
| format | Article |
| id | doaj.art-942a6cce0c9e4a1399f77c1e1bd0d13b |
| institution | Directory Open Access Journal |
| issn | 2667-3258 |
| language | English |
| last_indexed | 2024-04-24T20:11:10Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj.art-942a6cce0c9e4a1399f77c1e1bd0d13b2024-03-23T06:26:38ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582024-03-0142237245Allogenic microglia replacement: A novel therapeutic strategy for neurological disordersYanxia Rao0Bo Peng1Department of Laboratory Animal Science, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, ChinaDepartment of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200000, China.; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China; Corresponding author.Microglia are resident immune cells in the central nervous system (CNS) that play vital roles in CNS development, homeostasis and disease pathogenesis. Genetic defects in microglia lead to microglial dysfunction, which in turn leads to neurological disorders. The correction of the specific genetic defects in microglia in these disorders can lead to therapeutic effects. Traditional genetic defect correction approaches are dependent on viral vector-based genetic defect corrections. However, the viruses used in these approaches, including adeno-associated viruses, lentiviruses and retroviruses, do not primarily target microglia; therefore, viral vector-based genetic defect corrections are ineffective in microglia. Microglia replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy microglia. In this paper, we systematically review the history, rationale and therapeutic perspectives of microglia replacement, which would be a novel strategy for treating CNS disorders.http://www.sciencedirect.com/science/article/pii/S2667325823000778MicrogliaReplacementMicroglia replacementMicroglia depletionMicroglia-free nicheCSF1R |
| spellingShingle | Yanxia Rao Bo Peng Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders Fundamental Research Microglia Replacement Microglia replacement Microglia depletion Microglia-free niche CSF1R |
| title | Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders |
| title_full | Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders |
| title_fullStr | Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders |
| title_full_unstemmed | Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders |
| title_short | Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders |
| title_sort | allogenic microglia replacement a novel therapeutic strategy for neurological disorders |
| topic | Microglia Replacement Microglia replacement Microglia depletion Microglia-free niche CSF1R |
| url | http://www.sciencedirect.com/science/article/pii/S2667325823000778 |
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