Genetic Deletion of AT<sub>1a</sub> Receptor or Na<sup>+</sup>/H<sup>+</sup> Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice

Genetic Deletion of AT<sub>1a</sub> Receptor or Na<sup>+</sup>/H<sup>+</sup> Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice

The roles of angiotensin II (Ang II) AT<sub>1</sub> (AT<sub>1a</sub>) receptors and its downstream target Na<sup>+</sup>/H<sup>+</sup> exchanger 3 (NHE3) in the proximal tubules in the development of two-kidney, 1-clip (2K1C) Goldblatt hypertension hav...

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Bibliographic Details
Main Authors: Xiao Chun Li, Rumana Hassan, Ana Paula O. Leite, Akemi Katsurada, Courtney Dugas, Ryosuke Sato, Jia Long Zhuo
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
2-kidney
1-clip Goldblatt hypertension
angiotensin II
AT<sub>1a</sub> receptor
NHE3
proximal tubule
Online Access:https://www.mdpi.com/1422-0067/23/24/15798

Internet

https://www.mdpi.com/1422-0067/23/24/15798

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