A low-anticoagulant heparin suppresses metastatic dissemination through the inhibition of tumor cell-platelets association

A low-anticoagulant heparin suppresses metastatic dissemination through the inhibition of tumor cell-platelets association

Metastasis is the leading cause of cancer-related deaths. Despite this relevance, there is no specific therapy targeting metastasis. The interaction of the tumor cell with platelets, forming microemboli is crucial for successful hematogenous dissemination. Heparin disrupts it by a P-selectin-mediate...

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Bibliographic Details
Main Authors: Juliana M. Motta, Kayene V.A. Micheli, Carlos Roberto-Fernandes, Michelle Hermsdorff-Brandt, Alessandra L. Guedes, Flávia S. Frattani, Paulo A.S. Mourão, Mariana S. Pereira
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Metastasis
Heparin
P-selectin
Tumor cells
Platelets
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223019066

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http://www.sciencedirect.com/science/article/pii/S0753332223019066

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