Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Management

Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Management

Bis(pyrazol-1-yl)acetic acid (HC(pz)<sub>2</sub>COOH) and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid (HC(pz<sup>Me2</sup>)<sub>2</sub>COOH) were converted into the methyl ester derivatives <b>1</b> (L<sup>OMe</sup>) and <b>2</b>...

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Bibliographic Details
Main Authors: Maura Pellei, Carlo Santini, Luca Bagnarelli, Miriam Caviglia, Paolo Sgarbossa, Michele De Franco, Mirella Zancato, Cristina Marzano, Valentina Gandin
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
silver
bis(pyrazolyl)acetate ligands
anticancer activity
TrxR
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/24/4/4091

Internet

https://www.mdpi.com/1422-0067/24/4/4091

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