Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis

Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis

Abstract Background Photon radiation has been shown to stimulate the secretion of radioresistant factors from tumor cells, ultimately promoting tumor angiogenesis and metastasis. On the other hand, heavy-ion radiotherapy has been demonstrated to control tumor angiogenesis and metastasis levels. The...

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Chi tiết về thư mục
Những tác giả chính: Hao Huang, Ying Xu, Zi Guo, Miaomiao Zhang, Wanshi Li, Yidan Song, Jing Nie, Wentao Hu, Tom K. Hei, Guangming Zhou
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: BMC 2025-02-01
Loạt:Journal of Translational Medicine
Những chủ đề:
X-ray
Carbon ion
PRDM10-DT
TGF-β1
Angiogenesis
SP1
Truy cập trực tuyến:https://doi.org/10.1186/s12967-025-06273-0

Internet

https://doi.org/10.1186/s12967-025-06273-0

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