Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

Despite the controversial outcomes of clinical trials executed so far, the prevention of β-amyloid (Aβ) deposition and neurotoxicity by small molecule inhibitors of Aβ aggregation remains a target intensively pursued in the search of effective drugs for treating Alzheimer&...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Rosa Purgatorio, Modesto de Candia, Annalisa De Palma, Francesco De Santis, Leonardo Pisani, Francesco Campagna, Saverio Cellamare, Cosimo Damiano Altomare, Marco Catto
Natura:	Articolo
Lingua:	English
Pubblicazione:	MDPI AG 2018-06-01
Serie:	Molecules
Soggetti:	beta-amyloid aggregation inhibitors indolin-2-ones Alzheimer’s disease quantitative structure-activity relationships multitarget activity
Accesso online:	http://www.mdpi.com/1420-3049/23/7/1544

Documenti analoghi

Repositioning of Dantrolene as a Multitarget Agent for Neurodegenerative Diseases
di: Isabella Bolognino, et al.
Pubblicazione: (2019-08-01)

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease
di: Rosa Purgatorio, et al.
Pubblicazione: (2020-12-01)

Consensus Ensemble Multitarget Neural Network Model of Anxiolytic Activity of Chemical Compounds and Its Use for Multitarget Pharmacophore Design
di: Pavel M. Vassiliev, et al.
Pubblicazione: (2023-05-01)

Virtual screening and activity evaluation of multitargeting inhibitors for idiopathic pulmonary fibrosis
di: Rui Wang, et al.
Pubblicazione: (2022-09-01)

A Definition of “Multitargeticity”: Identifying Potential Multitarget and Selective Ligands Through a Vector Analysis
di: Juan Francisco Sánchez-Tejeda, et al.
Pubblicazione: (2020-03-01)

Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin–HDAC Inhibitor Hybrids as Multitarget Drugs
di: Lukas von Bredow, et al.
Pubblicazione: (2022-03-01)

Synthesis and biological activities of some indoline derivatives
di: Rode Milind A., et al.
Pubblicazione: (2009-01-01)

Synthesis and biological activities of some indoline derivatives
di: SAHEBRAO S. RINDHE, et al.
Pubblicazione: (2009-12-01)

Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study
di: Susana Barbosa-Méndez, et al.
Pubblicazione: (2024-05-01)

Drug discovery and computational strategies in the multitarget drugs era
di: Jéssika de Oliveira Viana, et al.
Pubblicazione: (2018-11-01)

Advances in Multitarget Therapeutic Approaches for Immune-Mediated Glomerular Diseases
di: Luminita Voroneanu, et al.
Pubblicazione: (2025-02-01)

Essential Paralogous Proteins as Potential Antibiotic Multitargets in Escherichia coli
di: Christine D. Hardy
Pubblicazione: (2022-12-01)

Biological Activity Profiles of Multitarget Ligands from X-ray Structures
di: Christian Feldmann, et al.
Pubblicazione: (2020-02-01)

An Efficient Multi-Path Multitarget Tracking Algorithm for Over-The-Horizon Radar
di: Yuan Huang, et al.
Pubblicazione: (2019-03-01)

Novel Multitarget Therapies for Lung Cancer and Respiratory Disease
di: Masako Yumura, et al.
Pubblicazione: (2020-09-01)

A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics
di: Rosa Purgatorio, et al.
Pubblicazione: (2024-01-01)

Detection of Mycoplasma genitalium in female cervical samples by Multitarget Real-Time PCR
di: Sabina Mahmutović-Vranić, et al.
Pubblicazione: (2007-05-01)

Exploration of multitargeted antialzheimer's activity of safflower leaves phytoconstituents: In silico molecular docking approach
di: Dolly Das, et al.
Pubblicazione: (2024-04-01)

Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives
di: Aliki Drakontaeidi, et al.
Pubblicazione: (2024-07-01)

Microwave synthesis, density functional theory study and antiproliferative activity of the novel spiropyrazole derivatives
di: Noora Asaad, et al.
Pubblicazione: (2024-10-01)

A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens
di: Debora Inacio Leite, et al.
Pubblicazione: (2023-04-01)

Scanless multitarget-matching multiphoton excitation fluorescence microscopy
di: Junpeng Qiu, et al.
Pubblicazione: (2018-03-01)

Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
di: Rafael Agustín Burgos, et al.
Pubblicazione: (2020-12-01)

Selecting Multitarget Peptides for Alzheimer’s Disease
di: Anne Kasus-Jacobi, et al.
Pubblicazione: (2022-09-01)

Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines via Inert C(sp3)-H Activation
di: Masafumi Nakanishi, et al.
Pubblicazione: (2012-04-01)

“Statistics 103” for Multitarget Tracking
di: Ronald Mahler
Pubblicazione: (2019-01-01)

Explaining Accurate Predictions of Multitarget Compounds with Machine Learning Models Derived for Individual Targets
di: Alec Lamens, et al.
Pubblicazione: (2023-01-01)

MULTITARGET ANTI-PD-1/PD-L1/CD19/CD25/CD38 THERAPY USING CHELATE NANOCOMPLEX MSC-428 IN ONCOPATHOLOGY
di: Lukyanchuk O. V., et al.
Pubblicazione: (2018-12-01)

Development and Application of Indolines in Pharmaceuticals
di: Huixin Wei, et al.
Pubblicazione: (2023-02-01)

Discovery of a Novel Multitarget Analgesic Through an In Vivo-Guided Approach
di: Guo Zhen, et al.
Pubblicazione: (2025-02-01)

Exploiting natural products to discover multitarget inhibitors of insect chitinolytic enzymes
di: Yi Ding, et al.
Pubblicazione: (2023-12-01)

Multitargeting nature of muscarinic orthosteric agonists and antagonists
di: Jaromir Myslivecek
Pubblicazione: (2022-09-01)

In Silico Studies on Compounds Derived from <i>Calceolaria</i>: Phenylethanoid Glycosides as Potential Multitarget Inhibitors for the Development of Pesticides
di: Marco A. Loza-Mejía, et al.
Pubblicazione: (2018-10-01)

Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H<sub>3</sub> Agents: Synthesis and Biological Evaluation
di: Quxiang Li, et al.
Pubblicazione: (2024-11-01)

Distributed Multitarget Tracking Based on Diffusion Strategies Over Sensor Networks
di: Yihua Yu, et al.
Pubblicazione: (2019-01-01)

Exact Closed-Form Multitarget Bayes Filters
di: Ronald Mahler
Pubblicazione: (2019-06-01)

Discovery of novel melatonin–mydroxyquinoline hybrids as multitarget strategies for Alzheimer’s disease therapy
di: Wei Wang, et al.
Pubblicazione: (2024-04-01)

Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease
di: Wen-Yu Wu, et al.
Pubblicazione: (2017-01-01)

Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect
di: Elix Alberto Domínguez-Mendoza, et al.
Pubblicazione: (2021-02-01)

A new binding mode for ecdysteroid analog tebufenozide as a multitargeted IGR with chitinase
di: Jia-lin Cui, et al.
Pubblicazione: (2024-09-01)