The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis

The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis

The risk of idiosyncratic drug-induced agranulocytosis (IDIAG) markedly constrains the use of clozapine, a neuroleptic with unparalleled efficacy. Most clozapine patients experience an early inflammatory response, likely a necessary step in IDIAG onset. However, most patients do not progress to IDIA...

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Bibliographic Details
Main Authors: Samantha Christine Sernoskie, Alison Jee, Jack Uetrecht
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
myeloperoxidase
MPO
clozapine
inflammation
Sprague Dawley rats
THP-1 macrophages
Online Access:https://www.mdpi.com/1422-0067/24/2/1243

Internet

https://www.mdpi.com/1422-0067/24/2/1243

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