General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism

General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism

Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelo...

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Bibliographic Details
Main Authors: Jianchen Cui, Jiho Park, Xianshu Ju, Yulim Lee, Boohwi Hong, Jeonghoon Ahn, Yoon Hee Kim, Youngkwon Ko, Seok-Hwa Yoon, Chaeseong Lim, Sun Yeul Lee, Sung-Oh Huh, Jun Young Heo, Woosuk Chung
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autism
anesthesia
BDNF (brain derived neurotrophic factor)
BTBR
E/I imbalance
mitochondrial respiration
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.772047/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.772047/full

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