Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions

Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to inhibit cell growth in a variety of cancers. However, the mechanisms are not completely understood, especially in colorectal cancer (CRC). A xe...

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Bibliographic Details
Main Authors: Eugene B. Chang, Mark W. Musch, Marc Bissonnette, Tong-Chuan He, Wei Du, Zejuan Li, Tyler Calway, Xiao-Dong Wen, Zhiyu Zhang, Guang-Jian Du, Chong-Zhi Wang, Chun-Su Yuan
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
ginsenoside
compound K
xenograft
cell cycle arrest
p53/p21
Online Access:http://www.mdpi.com/1422-0067/14/2/2980

Internet

http://www.mdpi.com/1422-0067/14/2/2980

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