Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas

Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas

Abstract Diffusely infiltrating gliomas are among the most common central nervous system tumors in adults. Over the past decade, the subcategorization of these tumors has changed to include both traditional histologic features and more recently identified molecular factors. However, one molecular fe...

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Bibliographic Details
Main Authors: Yan Liu, Adwait Amod Sathe, Kalil G. Abdullah, Samuel K. McBrayer, Steven H. Adams, Andrew J. Brenner, Kimmo J. Hatanpaa, Mariano S. Viapiano, Chao Xing, Jamie M. Walker, Timothy E. Richardson
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Acta Neuropathologica Communications
Subjects:
Glioma
Astrocytoma
Glioblastoma
Methylation profiling
Chromosomal instability
Copy number variation
Online Access:https://doi.org/10.1186/s40478-022-01339-2

Internet

https://doi.org/10.1186/s40478-022-01339-2

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