Is there a biological plausability for p53 codon 72 polymorphism influence on cervical cancer development?
The interaction between HPV E6 and p53 protein is known as the most important event in HPV-associated carcinogenesis. Some in vitro studies suggested that p53 genetic variants are targeted for ubiquitin-proteasome degradation induced by E6 with different abilities. A common p53 variant at position 7...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2011-02-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/335 |