The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

Translation fidelity is critical for protein synthesis and to ensure correct cell functioning. Mutations in the protein synthesis machinery or environmental factors that increase synthesis of mistranslated proteins result in cell death and degeneration and are associated with neurodegenerative disea...

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Bibliographic Details
Main Authors: Raquel M Silva, Iven C N Duarte, João A Paredes, Tatiana Lima-Costa, Michel Perrot, Hélian Boucherie, Brian J Goodfellow, Ana C Gomes, Denisa D Mateus, Gabriela R Moura, Manuel A S Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2667667?pdf=render

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http://europepmc.org/articles/PMC2667667?pdf=render

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