Long-distance effects of insertional mutagenesis.

Most common systems of genetic engineering of mammalian cells are associated with insertional mutagenesis of the modified cells. Insertional mutagenesis is also a popular approach to generate random alterations for gene discovery projects. A better understanding of the interaction of the structural...

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Bibliographic Details
Main Authors: Ruchi Singhal, Xiaotao Deng, Alex A Chenchik, Eugene S Kandel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3016401?pdf=render