hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translational regulation affecting cancer treatment in gliob...

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Bibliographic Details
Main Authors: Pauline Herviou, Morgane Le Bras, Leïla Dumas, Corinne Hieblot, Julia Gilhodes, Gianluca Cioci, Jean-Philippe Hugnot, Alfred Ameadan, François Guillonneau, Erik Dassi, Anne Cammas, Stefania Millevoi
Format: Article
Language:English
Published: Nature Portfolio 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16168-x

Internet

https://doi.org/10.1038/s41467-020-16168-x

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