In Silico Prediction of Plasma Concentrations of Fluconazole Capsules with Different Dissolution Profiles and Bioequivalence Study Using Population Simulation

In Silico Prediction of Plasma Concentrations of Fluconazole Capsules with Different Dissolution Profiles and Bioequivalence Study Using Population Simulation

A biowaiver is accepted by the Brazilian Health Surveillance Agency (ANVISA) for immediate-release solid oral products containing Biopharmaceutics Classification System (BCS) class I drugs showing rapid drug dissolution. This study aimed to simulate plasma concentrations of fluconazole capsules with...

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Bibliographic Details
Main Authors: Marcelo Dutra Duque, Daniela Amaral Silva, Michele Georges Issa, Valentina Porta, Raimar Löbenberg, Humberto Gomes Ferraz
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Pharmaceutics
Subjects:
fluconazole
biowaiver
dissolution
Biopharmaceutics Classification System (BCS)
bioequivalence
GastroPlus<sup>™</sup>
Online Access:https://www.mdpi.com/1999-4923/11/5/215

Internet

https://www.mdpi.com/1999-4923/11/5/215

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