Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.

Bibliographic Details
Main Authors: Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, Ksenia V. Kastanenka
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04268-x

Internet

https://doi.org/10.1038/s42003-022-04268-x

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