FASN negatively regulates p65 expression by reducing its stability via Thr254 phosphorylation and isomerization by Pin1

FASN negatively regulates p65 expression by reducing its stability via Thr254 phosphorylation and isomerization by Pin1

FASN, the sole cytosolic enzyme responsible for de novo palmitate synthesis in mammalian cells, has been associated with poor prognosis in cancer and shown to cause drug and radiation resistance by upregulating DNA damage repair via suppression of p65 expression. Targeting FASN by repurposing proton...

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Bibliographic Details
Main Authors: Lincoln Barlow, Sophia Josephraj, Boqing Gu, Zizheng Dong, Jian-Ting Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Journal of Lipid Research
Subjects:
FASN
isomerization
NF-κB
p65
phosphorylation
Pin1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524000348

Internet

http://www.sciencedirect.com/science/article/pii/S0022227524000348

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