Insights on the Multifaceted Roles of Wild-Type and Mutated Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis Pathogenesis

Insights on the Multifaceted Roles of Wild-Type and Mutated Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis Pathogenesis

Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neurodegenerative disease. Cell damage in ALS is the result of many different, largely unknown, pathogenetic mechanisms. Astrocytes and microglial cells play a critical role also for their ability to enhance a deranged inflammatory response....

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Bibliographic Details
Main Authors: Valentina Rubino, Giuliana La Rosa, Luca Pipicelli, Flavia Carriero, Simona Damiano, Mariarosaria Santillo, Giuseppe Terrazzano, Giuseppina Ruggiero, Paolo Mondola
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Antioxidants
Subjects:
Amyotrophic Lateral Sclerosis (ALS)
Superoxide Dismutase 1 (SOD1)
intracellular signaling
immune response regulation
excitotoxicity
neurodegeneration
Online Access:https://www.mdpi.com/2076-3921/12/9/1747

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https://www.mdpi.com/2076-3921/12/9/1747

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