scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells

scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells

Abstract Colorectal cancer (CRC) is one of the deadliest cancers worldwide, with the 5 year survival rate in metastatic cases limited to 12%. The design of targeted and effective therapeutics remains a major unmet clinical need in CRC treatment. Carcinoembryonic antigen (CEA), a glycoprotein overexp...

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Bibliographic Details
Main Authors: Maria José Silveira, Cláudia Martins, Tânia Cruz, Flávia Castro, Ângela Amorim-Costa, Kerry Chester, Maria José Oliveira, Bruno Sarmento
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Nanobiotechnology
Subjects:
Cancer therapy
Carcinoembryonic antigen
Drug delivery
Nanomedicine
Single-chain variable fragment functionalization
Targeted therapies
Online Access:https://doi.org/10.1186/s12951-023-02126-4

Internet

https://doi.org/10.1186/s12951-023-02126-4

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