A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma

A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma

Abstract Background Pancreatic adenocarcinoma (PAAD) is a severe malignant with a 5-year survival rate of approximately 9%. Oleanolic acid is a well-known natural triterpenoid which exhibits pharmacological activities. We previously synthesized a series of oleanolic acid derivatives and evaluated th...

Full description

Bibliographic Details
Main Authors: Shijia Wu, Yong Ai, Huimin Huang, Guangyu Wu, Shipeng Zhou, Weilong Hong, Percy David Papa Akuetteh, Guihua Jin, Xingling Zhao, Yihua Zhang, Xiaolong Zhang, Linhua Lan
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cancer Cell International
Subjects:
Oleanolic acid
Metabolic crisis
Glutaminolysis
YTHDF1
Redox homeostasis
Online Access:https://doi.org/10.1186/s12935-022-02562-6

Internet

https://doi.org/10.1186/s12935-022-02562-6

Similar Items