A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells

A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells

Abstract Background Genome-wide association studies (GWAS) have identified genetic variants linked to fat metabolism and related traits, but rarely pinpoint causative variants. This limitation arises from GWAS not considering functional implications of noncoding variants that can affect transcriptio...

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Bibliographic Details
Main Authors: Casimiro Castillejo-López, José Ramón Bárcenas-Walls, Marco Cavalli, Anders Larsson, Claes Wadelius
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Lipids in Health and Disease
Subjects:
Allele-specific SNPs
Functional variants
Genome editing
Differential gene expression
Phenotypic changes
Online Access:https://doi.org/10.1186/s12944-024-02029-9

Internet

https://doi.org/10.1186/s12944-024-02029-9

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