Histone Methyltransferase SETD1A Induces Epithelial-Mesenchymal Transition to Promote Invasion and Metastasis Through Epigenetic Reprogramming of Snail in Gastric Cancer

Histone Methyltransferase SETD1A Induces Epithelial-Mesenchymal Transition to Promote Invasion and Metastasis Through Epigenetic Reprogramming of Snail in Gastric Cancer

Aberrant epigenetic modification induces oncogene expression and promotes cancer development. The histone lysine methyltransferase SETD1A, which specifically methylates histone 3 lysine 4 (H3K4), is involved in tumor growth and metastasis, and its ectopic expression has been detected in aggressive m...

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Bibliographic Details
Main Authors: Jugang Wu, Hongjuan Chai, Haiyan Shan, Chunpeng Pan, Xin Xu, Wenpei Dong, Jiwei Yu, Yan Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SETD1A
gastric cancer
metastasis
snail
epigenetic reprogram
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.657888/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.657888/full

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