Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice.

Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice.

Acute exacerbations of pulmonary fibrosis are characterized by rapid decrements in lung function. Environmental factors that may contribute to acute exacerbations remain poorly understood. We have previously demonstrated that exposure to inhaled lipopolysaccharide (LPS) induces expression of genes a...

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Bibliographic Details
Main Authors: David M Brass, Jennifer C Spencer, Zhuowei Li, Erin Potts-Kant, Sarah M Reilly, Mary K Dunkel, Joseph D Latoche, Richard L Auten, John W Hollingsworth, Cheryl L Fattman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3397936?pdf=render

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http://europepmc.org/articles/PMC3397936?pdf=render

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