Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of...

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Detaylı Bibliyografya
Asıl Yazarlar: Ana Gil, Adriana Pabón, Silvia Galiano, Asunción Burguete, Silvia Pérez-Silanes, Eric Deharo, Antonio Monge, Ignacio Aldana
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: MDPI AG 2014-02-01
Seri Bilgileri:Molecules
Konular:
Plasmodium falciparum
antimalarial agents
quinoxaline
quinoxaline 1,4-di-N-oxide
chalcone
Online Erişim:http://www.mdpi.com/1420-3049/19/2/2166

Internet

http://www.mdpi.com/1420-3049/19/2/2166

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