Reducing White Adipose Tissue Browning Using p38α MAPK Inhibitors Ameliorates Cancer-Associated Cachexia as Assessed by Magnetic Resonance Imaging

Reducing White Adipose Tissue Browning Using p38α MAPK Inhibitors Ameliorates Cancer-Associated Cachexia as Assessed by Magnetic Resonance Imaging

Background: Up to 80% of pancreatic cancer patients suffer from cachexia. White adipose tissue (WAT) browning caused by the tumorigenicity and progression aggravates the cancer-associated cachexia (CAC). Cancer-initiated changes in the protein-38 mitogen-activated protein kinases (p38 MAPK) pathway...

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Bibliographic Details
Main Authors: Yufei Zhao, Jingyue Dai, Yang Jiang, Honghong Wu, Ying Cui, Xinxiang Li, Hui Mao, Binghui Wang, Shenghong Ju, Xin-Gui Peng
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Nutrients
Subjects:
cachexia
adipose tissue
pancreatic cancer
magnetic resonance imaging
p38 MAPK inhibitor
Online Access:https://www.mdpi.com/2072-6643/14/15/3013

Internet

https://www.mdpi.com/2072-6643/14/15/3013

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