Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model

Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model

Novel furoxan/coumarin hybrids were synthesized, and pharmacologic studies showed that the compounds displayed potent antiproliferation activities via downregulating both the phosphatidylinositide 3-kinase (PI3K) pathway and the mitogen-activated protein kinase (MAPK) pathway. To investigate the pre...

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Bibliographic Details
Main Authors: Yawen Yuan, Zhihong Li, Ke Wang, Shunguo Zhang, Qingfeng He, Lucy Liu, Zhijia Tang, Xiao Zhu, Ying Chen, Weimin Cai, Chao Peng, Xiaoqiang Xiang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
furoxan/coumarin hybrids
preclinical pharmacokinetics
LC-MS/MS method
physiologically based pharmacokinetic model
Online Access:https://www.mdpi.com/1420-3049/28/2/837

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https://www.mdpi.com/1420-3049/28/2/837

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