In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.

In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.

<h4>Purpose</h4>Imbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE). This study aimed to investigate whether [(18)F]-flumazenil ([(18)F]-FMZ) PET could be used to non-invasively characterise GABAA/centra...

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Bibliographic Details
Main Authors: Lucy Vivash, Marie-Claude Gregoire, Viviane Bouilleret, Alexis Berard, Catriona Wimberley, David Binns, Peter Roselt, Andrew Katsifis, Damian E Myers, Rodney J Hicks, Terence J O'Brien, Stefanie Dedeurwaerdere
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466212/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466212/?tool=EBI

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