Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2

Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2

Abstract Primary open angle glaucoma (POAG) features an optic neuropathy, elevated aqueous humor (AH) TGFβ2, and major risk factors of central corneal thickness (CCT), increasing age and intraocular pressure (IOP). We examined Tight skin (Tsk) mice to see if mutation of fibrillin-1, a repository for...

Full description

Bibliographic Details
Main Authors: MinHee K. Ko, Jeong-Im Woo, Jose M. Gonzalez, Gayeoun Kim, Lynn Sakai, Janos Peti-Peterdi, Jonathan A. Kelber, Young-Kwon Hong, James C. Tan
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14062-8

Internet

https://doi.org/10.1038/s41598-022-14062-8

Similar Items