Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes reduces chromatin accessibility at promoters

Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes reduces chromatin accessibility at promoters

Abstract Changes in gene expression programs are intimately linked to cell fate decisions. Post-translational modifications of core histones contribute to control gene expression. Methylation of lysine 4 of histone H3 (H3K4) correlates with active promoters and gene transcription. This modification...

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Main Authors: Mirna Barsoum, Alexander T. Stenzel, Agnieszka Bochyńska, Chao-Chung Kuo, Alexander Tsompanidis, Roksaneh Sayadi-Boroujeni, Philip Bussmann, Juliane Lüscher-Firzlaff, Ivan G. Costa, Bernhard Lüscher
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25881-0

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https://doi.org/10.1038/s41598-022-25881-0

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