The protease activated receptor 2 - CCAAT/enhancer-binding protein beta - SerpinB3 axis inhibition as a novel strategy for the treatment of non-alcoholic steatohepatitis

The protease activated receptor 2 - CCAAT/enhancer-binding protein beta - SerpinB3 axis inhibition as a novel strategy for the treatment of non-alcoholic steatohepatitis

Objective: The serine protease inhibitor SerpinB3 has been described as critical mediator of liver fibrosis and it has been recently proposed as an additional hepatokine involved in NASH development and insulin resistance. Protease Activated Receptor 2 has been identified as a novel regulator of hep...

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Bibliographic Details
Main Authors: Gianmarco Villano, Erica Novo, Cristian Turato, Santina Quarta, Mariagrazia Ruvoletto, Alessandra Biasiolo, Francesca Protopapa, Monica Chinellato, Andrea Martini, Elisabetta Trevellin, Marnie Granzotto, Stefania Cannito, Laura Cendron, Silvia De Siervi, Maria Guido, Maurizio Parola, Roberto Vettor, Patrizia Pontisso
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Metabolism
Subjects:
Serpins
Genetically manipulated mice
Experimental NASH
Transcription factors
Therapeutic drugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000206

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http://www.sciencedirect.com/science/article/pii/S2212877824000206

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