Physiological and Functional Effects of Dominant Active TCRα Expression in Transgenic Mice

Physiological and Functional Effects of Dominant Active TCRα Expression in Transgenic Mice

A T cell receptor (TCR) consists of α- and β-chains. Accumulating evidence suggests that some TCRs possess chain centricity, i.e., either of the hemi-chains can dominate in antigen recognition and dictate the TCR’s specificity. The introduction of TCRα/β into naive lymphocytes generates antigen-spec...

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Bibliographic Details
Main Authors: Anastasiia A. Kalinina, Rustam Kh. Ziganshin, Yulia Yu. Silaeva, Nina I. Sharova, Margarita F. Nikonova, Nadezda A. Persiyantseva, Tatiana G. Gorkova, Elena E. Antoshina, Lubov S. Trukhanova, Almira D. Donetskova, Victoria V. Komogorova, Marina M. Litvina, Alexander N. Mitin, Maria A. Zamkova, Alexandra V. Bruter, Ludmila M. Khromykh, Dmitry B. Kazansky
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
chain-centric TCR
dominant active TCRα
allogeneic immune response
thymic involution
TCR repertoire
proteomics
Online Access:https://www.mdpi.com/1422-0067/24/7/6527

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https://www.mdpi.com/1422-0067/24/7/6527

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