Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier

Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier

Glioblastoma (GBM) is the most aggressive malignant brain tumor and has a high mortality rate. Photodynamic therapy (PDT) has emerged as a promising approach for the treatment of malignant brain tumors. However, the use of PDT for the treatment of GBM has been limited by its low blood‒brain barrier...

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Bibliographic Details
Main Authors: Thuy Giang Nguyen Cao, Ji Hee Kang, Su Jin Kang, Quan Truong Hoang, Han Chang Kang, Won Jong Rhee, Yu Shrike Zhang, Young Tag Ko, Min Suk Shim
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Extracellular vesicle
Chlorin e6
Triphenylphosphonium
Mitochondria-targeting photosensitizer
Photodynamic therapy
Blood‒brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001132

Internet

http://www.sciencedirect.com/science/article/pii/S2211383523001132

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