Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

Summary: Mutations that cause familial Alzheimer’s disease (FAD) are found in amyloid precursor protein (APP) and presenilin, the catalytic component of γ-secretase, that together produce amyloid β-peptide (Aβ). Nevertheless, whether Aβ is the primary disease driver remains controversial. We report...

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Bibliographic Details
Main Authors: Sujan Devkota, Rui Zhou, Vaishnavi Nagarajan, Masato Maesako, Hung Do, Arshad Noorani, Caitlin Overmeyer, Sanjay Bhattarai, Justin T. Douglas, Anita Saraf, Yinglong Miao, Brian D. Ackley, Yigong Shi, Michael S. Wolfe
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000895

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http://www.sciencedirect.com/science/article/pii/S2211124724000895

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