A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening

A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening

The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, arrests the cell cycle of the G2 phase, and this Vpr-mediated G2 arrest is implicated in an efficient HIV-1 spread in monocyte-derived macrophages. Here, we screened new candidates for Vpr-targeting HIV-1 inhibitors by using fis...

Full description

Bibliographic Details
Main Authors: Hirotaka Sato, Tomoyuki Murakami, Ryosuke Matsuura, Masako Abe, Seiji Matsuoka, Yoko Yashiroda, Minoru Yoshida, Hirofumi Akari, Yosuke Nagasawa, Masami Takei, Yoko Aida
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
HIV-1
Vpr
HIV-1 inhibitor
G2 arrest
fission yeast
human monocyte-derived macrophages
Online Access:https://www.mdpi.com/1999-4915/14/6/1321

Internet

https://www.mdpi.com/1999-4915/14/6/1321

Similar Items