Extraction of ADP-Heptose and Kdo<sub>2</sub>-Lipid A from <i>E. coli</i> Deficient in the Heptosyltransferase I Gene

Extraction of ADP-Heptose and Kdo<sub>2</sub>-Lipid A from <i>E. coli</i> Deficient in the Heptosyltransferase I Gene

The enzymes involved in lipopolysaccharide (LPS) biosynthesis, including Heptosyltransferase I (HepI), are critical for maintaining the integrity of the bacterial cell wall, and therefore these LPS biosynthetic enzymes are validated targets for drug discovery to treat Gram-negative bacterial infecti...

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Bibliographic Details
Main Authors: Jozafina Milicaj, Colleen D. Castro, Nadiya Jaunbocus, Erika A. Taylor
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Applied Sciences
Subjects:
Heptosyltransferase I
lipopolysaccharide biosynthesis
ADP-Heptose
Kdo<sub>2</sub>-Lipid A
Online Access:https://www.mdpi.com/2076-3417/11/18/8314

Internet

https://www.mdpi.com/2076-3417/11/18/8314

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