Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs. However, very little Aβ is associated with EVs compared with the total amount Aβ present in human plasma, C...

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Bibliographic Details
Main Authors: Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neurobiology of Disease
Subjects:
Sphingomyelinase
nSMase2
Long term potentiation
LTP
Ceramide
Extracellular vesicles (EVs)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000013

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http://www.sciencedirect.com/science/article/pii/S0969996123000013

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