Inhibition of Streptococcus mutans adhesion and biofilm formation with small-molecule inhibitors of sortase A from Juniperus chinensis

Inhibition of Streptococcus mutans adhesion and biofilm formation with small-molecule inhibitors of sortase A from Juniperus chinensis

Background Streptococcus mutans, an important Gram-positive pathogen in dental caries, uses sortase A (SrtA) to anchor surface proteins to the bacterial cell wall, thereby promoting biofilm formation and attachment to the tooth surface.Design Based on activity-guided separation, inhibitors of S. mut...

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Bibliographic Details
Main Authors: Eunji Cho, Ji-Yeon Hwang, Jae Sung Park, Daehyun Oh, Dong-Chan Oh, Hyeung-Geun Park, Jongheon Shin, Ki-Bong Oh
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Oral Microbiology
Subjects:
Adhesion
biofilm formation
Juniperus chinensis
sortase A inhibitor
Streptococcus mutans
Online Access:https://www.tandfonline.com/doi/10.1080/20002297.2022.2088937

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https://www.tandfonline.com/doi/10.1080/20002297.2022.2088937

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