HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing

HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing

Abstract The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed repair (HDR) of protein-blocked DSBs requires DNA end resection that is initiated by the endonuclease activity of the MRE11 complex....

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Bibliographic Details
Main Authors: Giordano Reginato, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, Vincent Morin, Elda Cannavo, Ilaria Ceppi, Stefan Braunshier, Ananya Acharya, Virginie Ropars, Jean-Baptiste Charbonnier, Martin Jinek, Andrè Nussenzweig, Taekjip Ha, Petr Cejka
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-50080-y

Internet

https://doi.org/10.1038/s41467-024-50080-y

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