BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

KELCH-ECH-associated protein 1 (KEAP1) is an adaptor protein of Cullin 3 (CUL3) E3 ubiquitin ligase that targets a redox sensitive transcription factor, NF-E2-related factor 2 (NRF2). BRCA1-associated protein 1 (BAP1) is a tumor suppressor and deubiquitinase whose mutations increase the risk of seve...

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Bibliographic Details
Main Authors: Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo, Kyeong Lee, Young-Ah Suh, Dalyong Kim, Woo Kyung Kim, Chi-Yeon Lim, Haeseung Lee, Young-Sam Keum
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
NF-E2-related factor 2 (NRF2)
KELCH-like ECH-associated protein 1 (KEAP1)
BRCA1-associated protein 1 (BAP1)
deubiquitinase (DUB)
lung adenocarcinoma (LUAD)
Online Access:https://www.mdpi.com/2076-3921/11/1/114

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https://www.mdpi.com/2076-3921/11/1/114

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