RGMa Participates in the Blood–Brain Barrier Dysfunction Through BMP/BMPR/YAP Signaling in Multiple Sclerosis

RGMa Participates in the Blood–Brain Barrier Dysfunction Through BMP/BMPR/YAP Signaling in Multiple Sclerosis

The infiltration of inflammatory cells into the central nervous system (CNS) through the dysfunctional blood–brain barrier (BBB) was critical in the early stages of MS. However, the mechanisms underlying BBB dysfunction remain unknown. Repulsive guidance molecule-a (RGMa) is involved in the pathogen...

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Bibliographic Details
Main Authors: Lei Zhang, Shi Tang, Yue Ma, Junhang Liu, Philippe Monnier, Hang Li, Rongrong Zhang, Gang Yu, Mengjie Zhang, Yongmei Li, Jinzhou Feng, Xinyue Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
blood–brain barrier
repulsive guidance molecule-a
bone morphogenetic protein
yes-associated protein
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.861486/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.861486/full

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