GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis

GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis

Abstract Glutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated in tumor tissues of hepatocellular carcinoma (HCC) patients by proteomics study. To explore its role in the progression of HCC, the expressional level of GLUD1 was...

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Bibliographic Details
Main Authors: Qianwei Zhao, Mengdan Yu, Jinxia Li, Yaoyu Guo, Zexuan Wang, Kefei Hu, Fang Xu, Yixian Liu, Lili Li, Didi Wan, Ying Zhao, Jian Shang, Jintao Zhang
Format: Article
Language:English
Published: Springer 2024-01-01
Series:Discover Oncology
Subjects:
GLUD1
Metabolism
ROS
p38/JNK MAPK pathway
Apoptosis
Online Access:https://doi.org/10.1007/s12672-024-00860-1

Internet

https://doi.org/10.1007/s12672-024-00860-1

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