The Stimulatory Effect of MIP-1α on the Gene Transduction Efficacy of Cord Blood CD34+ Cells by a Pseudotype Retroviral Vector

The Stimulatory Effect of MIP-1α on the Gene Transduction Efficacy of Cord Blood CD34+ Cells by a Pseudotype Retroviral Vector

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Introduction: Hematopoietic stem cells are always in a quiescence state. Since they need retroviral transduction to infect dividing cells, they are resistant to retrovirus transduction. They need to be pre-stimulated by a cytokine cocktail. For proliferation without maturation, we suggest MIP-1α as...

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Bibliographic Details
Main Authors: Kamran Alimoghaddam, L Moezzi, Hamid Ghaffari, Alireza Arjmand, P Ghodsi, Bahram Chahardouli, S Shahrokhi, Ardeshir Ghavamzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2009-06-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Gene Transduction
MIP-1α
Retroviral Vector
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/212

Internet

https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/212

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