Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis

Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis

As a severe neurological deficit, intracerebral hemorrhage (ICH) is associated with overwhelming mortality. Subsequent oxidative stress and neurological dysfunction are likely to cause secondary brain injury. Therefore, this study sought to define the role of Krüppel-like factor 6 (KLF6) and underly...

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Bibliographic Details
Main Authors: Jia Sun, Jinzhong Cai, Junhui Chen, Siqiaozhi Li, Xin Liao, Yixuan He, Xudong Chen, Sean Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
intracerebral hemorrhage
nuclear transcription factor
Krüppel like factor 6
sirtuin 5
Nrf2
HO-1
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.646729/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.646729/full

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