An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia

An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia

BackgroundChronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19+ CD5+ B cells but its origin remains debated. Mutated CLL may originate from post-germinal center B cells and unmutated CLL from CD5+ mature B cell precursors. Irrespective of precursor types, events initiating CL...

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Bibliographic Details
Main Authors: Md Ashik Ullah, Beatriz Garcillán, Eden Whitlock, William A. Figgett, Simona Infantino, Mahya Eslami, SiLing Yang, M. Arifur Rahman, Yong H. Sheng, Nicholas Weber, Pascal Schneider, Constantine S. Tam, Fabienne Mackay
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
chronic lymphocytic leukemia
BAFF
APRIL
TCL1-Tg mice model
leukemia initiation
leukemia dissemination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1345515/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1345515/full

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