Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging

Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer’sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important ri...

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Bibliographic Details
Main Authors: Qirui Zhang, Lingli Wu, Chao Du, Kai Xu, Jinping Sun, Junying Zhang, He Li, Xin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00183/full