Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging
Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer’sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important ri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2020.00183/full |
| _version_ | 1829479889574559744 |
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| author | Qirui Zhang Lingli Wu Lingli Wu Chao Du Chao Du Kai Xu Kai Xu Jinping Sun Junying Zhang He Li Xin Li Xin Li |
| author_facet | Qirui Zhang Lingli Wu Lingli Wu Chao Du Chao Du Kai Xu Kai Xu Jinping Sun Junying Zhang He Li Xin Li Xin Li |
| author_sort | Qirui Zhang |
| collection | DOAJ |
| description | Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer’sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. However, it remains unknown whether rs405509 affects brain functional connectivity (FC) in aging.Methods: We investigated the effect of the rs405509 genotype (T/T vs. G-allele) on age-related brain FC using functional magnetic resonance imaging. Forty-five elderly TT carriers and 45 elderly G-allele carriers were scanned during a working memory (WM) task.Results: We found that TT carriers showed an accelerated age-related increase in functional activation in the left postcentral gyrus compared with G-allele carriers. Furthermore, the FC between the left postcentral gyrus and some key regions during WM performance, including the right caudal and superior frontal sulcus (SFS), was differentially modulated by age across rs405509 genotype groups.Conclusions: These results demonstrate that the rs405509 T/T allele of APOE causes an age-related brain functional decline in nondemented elderly people, which may be beneficial for understanding the neural mechanisms of rs405509-related cognitive aging and AD pathogenesis. |
| first_indexed | 2024-12-14T17:46:32Z |
| format | Article |
| id | doaj.art-94777c2d258b4d1da6eb266cecff0686 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T17:46:32Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-94777c2d258b4d1da6eb266cecff06862022-12-21T22:52:44ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-06-011210.3389/fnagi.2020.00183534916Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented AgingQirui Zhang0Lingli Wu1Lingli Wu2Chao Du3Chao Du4Kai Xu5Kai Xu6Jinping Sun7Junying Zhang8He Li9Xin Li10Xin Li11Institute of Criminology, People’s Public Security University of China, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, ChinaBABRI Centre, Beijing Normal University, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, ChinaBABRI Centre, Beijing Normal University, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, ChinaBABRI Centre, Beijing Normal University, Beijing, ChinaThe Affiliated Hospital of Qingdao University, Shandong, ChinaBABRI Centre, Beijing Normal University, Beijing, ChinaBABRI Centre, Beijing Normal University, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, ChinaBABRI Centre, Beijing Normal University, Beijing, ChinaBackground: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer’sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. However, it remains unknown whether rs405509 affects brain functional connectivity (FC) in aging.Methods: We investigated the effect of the rs405509 genotype (T/T vs. G-allele) on age-related brain FC using functional magnetic resonance imaging. Forty-five elderly TT carriers and 45 elderly G-allele carriers were scanned during a working memory (WM) task.Results: We found that TT carriers showed an accelerated age-related increase in functional activation in the left postcentral gyrus compared with G-allele carriers. Furthermore, the FC between the left postcentral gyrus and some key regions during WM performance, including the right caudal and superior frontal sulcus (SFS), was differentially modulated by age across rs405509 genotype groups.Conclusions: These results demonstrate that the rs405509 T/T allele of APOE causes an age-related brain functional decline in nondemented elderly people, which may be beneficial for understanding the neural mechanisms of rs405509-related cognitive aging and AD pathogenesis.https://www.frontiersin.org/article/10.3389/fnagi.2020.00183/fullAPOE promoterbrain connectomefronto-parietal networkworking memoryaging |
| spellingShingle | Qirui Zhang Lingli Wu Lingli Wu Chao Du Chao Du Kai Xu Kai Xu Jinping Sun Junying Zhang He Li Xin Li Xin Li Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging Frontiers in Aging Neuroscience APOE promoter brain connectome fronto-parietal network working memory aging |
| title | Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging |
| title_full | Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging |
| title_fullStr | Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging |
| title_full_unstemmed | Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging |
| title_short | Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging |
| title_sort | effects of an apoe promoter polymorphism on fronto parietal functional connectivity during nondemented aging |
| topic | APOE promoter brain connectome fronto-parietal network working memory aging |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2020.00183/full |
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