Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice
ObjectiveTo determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis.Approach and ResultsUsing a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with the Ldlr–/– mous...
| Hlavní autoři: | , , , , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
Frontiers Media S.A.
2020-06-01
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| Edice: | Frontiers in Physiology |
| Témata: | |
| On-line přístup: | https://www.frontiersin.org/article/10.3389/fphys.2020.00714/full |