Knockout of C1q/tumor necrosis factor-related protein-9 aggravates cardiac fibrosis in diabetic mice by regulating YAP-mediated autophagy

Knockout of C1q/tumor necrosis factor-related protein-9 aggravates cardiac fibrosis in diabetic mice by regulating YAP-mediated autophagy

IntroductionDiabetic cardiomyopathy (DCM) is predominantly distinguished by impairment in ventricular function and myocardial fibrosis. Previous studies revealed the cardioprotective properties of C1q/tumor necrosis factor-related protein 9 (CTRP9). However, whether CTRP9 affects diabetic myocardial...

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Bibliographic Details
Main Authors: Shiyan Ruan, Jun Li, Shengyun Lei, Shaomeng Zhang, Dan Xu, Anju Zuo, Linxi Li, Yuan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Pharmacology
Subjects:
diabetic cardiomyopathy
CTRP9
fibrosis
autophagy
YAP
fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1407883/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1407883/full

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