Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Summary: This study investigates the efficacy of proteomic analysis of human remains to identify active infections in the past through the detection of pathogens and the host response to infection. We advance leprosy as a case study due to the sequestering of sufferers in leprosaria and the suggesti...

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Bibliographic Details
Main Authors: Shevan Wilkin, Liam T. Lanigan, Nuria Montes, Mukul Sharma, Charlotte Avanzi, Donikë Sejdiu, Kerttu Majander, Saskia Pfrengle, Yun Chiang, Laura Kunz, Antje Dittmann, Frank Rühli, Pushpendra Singh, Maria Fontanals Coll, Matthew J. Collins, Alberto J. Taurozzi, Verena J. Schuenemann
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:iScience
Subjects:
Biochemistry
Biochemistry applications
Biochemistry methods
Medical biochemistry
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422400885X

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http://www.sciencedirect.com/science/article/pii/S258900422400885X

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