Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen
Summary: This study investigates the efficacy of proteomic analysis of human remains to identify active infections in the past through the detection of pathogens and the host response to infection. We advance leprosy as a case study due to the sequestering of sufferers in leprosaria and the suggesti...
Main Authors: | Shevan Wilkin, Liam T. Lanigan, Nuria Montes, Mukul Sharma, Charlotte Avanzi, Donikë Sejdiu, Kerttu Majander, Saskia Pfrengle, Yun Chiang, Laura Kunz, Antje Dittmann, Frank Rühli, Pushpendra Singh, Maria Fontanals Coll, Matthew J. Collins, Alberto J. Taurozzi, Verena J. Schuenemann |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-05-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422400885X |
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